First of all, I am new to these forums, but they seem inspiring and helpful. I have some newbie weight lifting questions (I apologize if they have been asked before).
I am a 21 year old female who has about 45ish pounds to lose (I am 5'5 185, I'd like to be anywhere between 135-145). I have NROL4W, but I did a search, and it seems like there is some conflicting info as to whether or not it is the best way to lose weight. My goal, like I said, is to lose weight. Do you think NROL4W is the most effective way to do that? If not, what would you suggest-full body, 2 day split, etc.
I run 3-4x a week (when I'm not injured, which has been most of the past year, but I think I'm ok now).
I know that diet plays a HUGE role in weight loss, but I'm still not sure about lifting weights.
I'm editing to say that I have never lifted weights consistently. Not sure if it's relevant or not, but there ya go.
Diet plays THE role in losing weight, not lifting weights. Lifting may help to preserve muscle while you are in a deficit diet but it should not be your source for losing the weight.
Yes, you can. Assuming you eat less than you expend, and you take into account how the intensity of the workouts affect your activity levels for the rest of the day and be sure your diet reflects your ACTUAL burn, not what you think you burn but then don't because you're flopped on the couch when you're not working out.
If you look through the threads in the forum for the book, you'll see that people have done just fine, or they've found they end up not doing anything the rest of the day and therefore eat too much to lose.
Best way to figure out your reaction is to give it a try and see what happens… unless you already know you're either still active or not the rest of the day with intense exercise programs.
Welcome.
(and yes, often these kinds of things are all a matter of "it depends")
I've got to go with Bob on this one. Diet is THE main determinant in weight loss in my opinion. If you eat more calories than you burn you will never lose weight.
That being said the NROL4W subforum is good. I would ask the same question in there. I think I read an answer once that said NROL4W is good but there might be better since I don't think it's specifically a fat loss program but without looking through the forum I can't say for sure.
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Past performance is not indicative of future success.
Never argue with an idiot. They drag you down to their level and beat you with experience.
Being at a caloric deficit is what will get the weight off. If a workout burns 300 calories, you can do that or you can skip the cookies - either one makes a deficit for you. But if you want a 700-1000 calorie deficit (or more) per day, most of that will have to be from diet.
What weight training does for you is make you stronger, help your bones, make your everyday life easier, give you confidence and a body that can do stuff. Plus, make sure that once you slim down there is something underneath to show for all your work.
NROL4W, as you have read, is written to bust myths that many people might hold about weight training in general and women in particular. If you are looking to lose a size or two and change your body composition then the diet & exercise recommendations are great. You eat at about maintenance and add weight training and things will change. But, that might not be the program that you want to lose 40-50 pounds.
Some people have found that eating at a big deficit and doing the training from NROL4W is too much all at once - it leaves them wiped out and by being a slug the other 23 hours of the day the results are not what is wanted. Others do the program just fine on a big deficit. Others do the program on a small deficit and see the body recomp as described in the book (almost same weight, smaller size & more firm).
It really is YMMV.
If you are a beginner to working with weights, almost any well-written program using the big moves will be fine for you.
Newbie Question-Weight Loss & NROL4W
. I kind of figured that it was a "it really depends" kind of thing. 
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