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Old 07-05-2005, 01:31 PM   #1 (permalink)
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I just read about this in Men's Fitness. I'm intrigued, but also skeptical.
Please take a look at the link and post your opinions and ideas. Thanks in advance.

http://www.endothil.com
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Old 07-05-2005, 01:59 PM   #2 (permalink)
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Download the "research" study. I'm no expert but it smells like BS to me. Here's a quote from the study..

"Recently, a compound has been discovered that contains a naturally occurring active molecule known to activate the a7-nar. This molecule is the core substance in Endothil™-CR (ECR). It is theorized that, based on its ability to interact with a7-nars, the active molecule in ECR should stimulate the migration of progenitor cells from bone marrow and blood stream in much the same way that exercising to exhaustion does."

I would save your money.
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Old 07-05-2005, 02:11 PM   #3 (permalink)
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Aren't you already the "fittest man ever seen"?

I smell the same as UpNorth.
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Old 07-05-2005, 02:12 PM   #4 (permalink)
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Quote:
I would save your money.
...and your health, didnt even read the article, but why try anything like that? BUT, if you do, fill us all in [img]tongue.gif[/img]
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Old 07-05-2005, 09:49 PM   #5 (permalink)
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Quote:
Originally posted by OldGuy:
Aren't you already the "fittest man ever seen"?
That's only one guy's opinion. I'm more interested in what I see in the mirror. [img]smile.gif[/img] I say I'm a long way away from what I want... but at least on the right track and not just sitting there.


I'm not saying I'm going to get the stuff, just the first I heard of it and wondered if anyone here had. I really can't afford an extra $60 a month.
I tried to find as much stuff as I could via search engine but I couldnt find the research results. I'll have to look again.
As you all mention.... I think I hear my B.S. detector going off..........
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Old 07-06-2005, 11:10 AM   #6 (permalink)
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Where do I start?

First off, the research summary doesn't even approach minimum standards of clinical trials reporting. We don't know anything about who was recruited into the trial, what they were given to do, how the random sequence of allocation was generated, how the subjects were allocated to this sequence, how the subjects were kept blinded to their allocation, what their baseline characteristics were, what their ACTUAL VALUES for each of the outcomes were, what the variance around those outcomes were, how many comparison tests were done, using what staistical test or tests.

Add to that the fact that the ONLY results from this "trial" were two significant p-values for "upper and lower body strength" (what the hell is this exactly?) and biceps circumference (and who the hell just publishes only p-values anymore??); despite the fact that body fat, lean body mass, body weight and body mass index were measured. This means that at least eight variables were tested, (likely using a t-test, I'm guessing, with no assessment of assumptions). That means that there's more than a 50% probability that at least one of those p-values is a spurious one (i.e. one that is less than 0.05 by chance alone).

My question is, what the heck is this doing in a fairly responsible publication like Men's Fitness? Was it an ad?
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Old 07-06-2005, 10:04 PM   #7 (permalink)
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That's what I thought too Bryan. You know in the mags how it lists that the "article" is an advertisement at the bottom or side of the pages??? this didn't. I couldnt tell if it was advertisement or not (although it certainly did seem like it). I'm sure that was their strategy. I was kind of surprised by it being in there also. You make some very, very good points.
Thanks for your thoughts.
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