Six subjects per group is not much of a concern as their method provides relatively low variability and provides adequate statistical power from that number (the joy of crossover trials)
12 sets of exercise for the legs with teh aim of eliciting failure within 8-10 reps with 2minutes between sets is reasonably representative of a single training session. I know I go nowhere near 12 sets, let alone 12 sets to failure.
Other work out of Stuarts lab shows have shown that his acute results feed out into the chronic setting as well, as he had earlier predicted with chronic resistance training being the accumulation of individual sessions.
Interestingly enough, the dosage that achieved the peak muscle FSR is pretty much inline with earlier work that measured peak rates of protein synthesis at rest with administration of essential amino acids (which work backwards to a dose of WPI around 18grams - for the same weight)
But protein synthesis is only one endpoint to measure...
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