I haven't heard anything on it not being safe...as far as I know it is.
what I can tell you though is that, from my personal experience, it's a waste.
I tried NO2, as well as the Pinacle 1/2 price imitation NOX2. Neither one did anything for me.
When NO2 1st came out, I heard all the hype as well. But in the last 6 months or so, all the reviews I've heard have not been very favorable.
hope this helps-
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