I did. I posted my "heaviest" picture in my log, but this is me at 215:
Spring of 2002, I started working out. I got down to 160 after months of cardio & weight lifting (took about 6-8 months, if I remember correctly). Granted, I stuck to the weights machines so I don't think it was "ideal" weightlifting but it worked. I noticed, through the months of exercising, that when I left the weights out, my weight loss slowed. About 2 years after my start, I was down to 150. I've gone between 150 and 165 since then, and am now about 148 and moving downward. I plan to stay under 155 for the rest of my life. Maybe even under 150.
I've kept the weight off for years by eating a lot better than I did (portion control, mostly - no seconds unless it's salad/veggies) and finding ways to stay active. I've also found that, in trying various things like yoga and running, I enjoy weightlifting the most.