Re-post.
Contrary to common knowledge, it's not the CNS that ultimately fatigues. In all likelihood, the CNS is the rate-limiter for muscular fatigue. In other words, you can never truly fatigue the CNS, since it governs the absolute limits of motor unit recruitment, oxygen kinetics, etc. In fact, all physiological functions are quite possibly governed by CNS control, to ensure that we can only voluntarily do so much before our own survival is threatened.
Of course there are practical considerations, for example, you wouldn't want to do sprints to a point of frequency through the week that impinges upon recovery from lower extremity training, as indicated by DOMS overlap. These things will vary not only with the individual program, but with idividual recovery ability.
Basically, all this talk about CNS fatigue is misunderstood & overrated, especially when we're talking about the general population who is not likely to cross over into exercise volume/magnitudes that warrent any real concern. And in the latter case, chronic (& acute) joint injuries are a much more pressing issue than the potential for neural fatigue.
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