I generally have a glass or two myself with dinner. The trouble with it is that it essentially shuts down fat oxidation until the alcohol is processed (that's probably an oversimplification, but it gets the point across).
So does it get in the way? A little, but I think one or two glasses a day isn't a huge a problem, provided they're actually what's considered true 4-ounce glasses and not the double serving most people pass off as a "glass."
In my experience, the main problem is when you're trying to get "shredded" not simply just get lean. This is when you need every advantage you can get. So at some point, say, if you're trying to get from 10 percent to 8 percent bodyfat, it may be problematic.
On the plus side, alcohol has even a greater thermic effect than protein!
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